Blach-Olszewska, Z, Janusz, M. Stimulatory effect of ovine colostrinine (a proline-rich polypeptide) on interferons and tumor necrosis factor product by murine resident peritoneal cells. Archivum Immunologiae et Therapie Experimentalis (Warsaw) 45(1):43-47 (1997). Colostrinin stimulates the production of tumor necrosis factor-alpha (TNF-a) and interferon-beta (INF-ß), both important cytokines in the inflammatory response.
Bocci, V, et al. What is the role of cytokines in human colostrum? Journal of Biologic Regulatory and Homeostatic Agents 5(4):121-124 (1991). The cytokines present in colostrum, such as TNF-a, interferon-g, IL-1 and IL-6, have an immunostimulatory effect. This could be significant for aged people or others with immunodeficiency.
Bessler, H., et al. Human colostrum stimulates cytokine production. Biology of the Neonate 69(6):376-382 (1996). Colostrum has also been shown to stimulate the production of certain cytokines, IL-1, IL-3 and IL-6, in peripheral white blood cells (monocytes).
Bogdan, C, Nathan, C. Modulation of macrophage function by transforming growth factor beta, interleukin-4, and interleukin-10. Annals of the New York Academy of Science 685:713-739 (1993). Certain cytokines found in colostrum, TGF-ß, IL-4 and IL-10, have a modulatory effect on macrophages, either stimulating or deactivating them as conditions dictate.
Feldmann, M, et al. Cytokines in autoimmune disorders. International Review of Immunology 17(1-4)217-228 (1998). Cytokines are important protein mediators of immunity, inflammation, cell proliferation, differentiation, fibrosis, and so forth, in other words, all the major biological processes which underlie autoimmune disorders. Modulating the effects of these cytokines, particularly TNF-a, can result in amelioration of the symptoms of the disorders.
Hagiwara, K, et al. Detection of cytokines in bovine colostrum. Veterinary Immunology and Immunopathology 76:183-190 (2000).
Inglot, A.D., et al. "Colostrinine: a proline-rich polypeptide from ovine colostrum is a modest cytokine inducer in human leukocytes." Arch Immunol Ther Exp (Wasz), 1996;44(4):215-224.
Zoltan P. Rona, M.D., M.Sc., Bovine Colostrum Emerges as Immunity Modulator, American Journal of Natural Medicine, March 1998.